Endocrine Abstracts

The observed increase in the incidence of Hashimoto’s thyroiditis (HT) requires the research on environmental factors that may initiate or model its course. There have been reports of the impact of vitamin D3 deficiency on HT development.Objective: To assess the degree of deficiency of 25OHD3 and the relationship between the disease duration and 25OHD3 levels in patients with HT.Material and methods: 310 people were enrolled i...

Introduction: In case of isolated adrenal metastases, complete surgical resection of the disease is a potentially curative treatment. Minimally invasive adrenalectomy is recommended in most patients with focal adrenal lesions without evidence of local invasion. However, data on surgical outcomes and survival after laparoscopic adrenalectomy (LA) for adrenal metastases are still lacking to clearly define the role of this procedure in the management of metastatic disease. <p...

Introduction: Pheochromocytomas are rarely diagnosed in pregnancy. The consequences of pheochromocytoma during pregnancy can be devastating for both mother and fetus. Effective treatment requires an accurate and early diagnosis, but sometimes the tumor is diagnosed relatively late, so it is absolutely necessary to respond quickly and effectively.Purpose: The aim of our study is to describe a patient with a history of medullary thyroid cancer who underwen...

Introduction: In ATA recommendations (2016) a delayed risk stratification (DRS) system proposed by D.P. Momesso et al. was accepted as a diagnostic tool for the risk stratification of unfavorable clinical outcome and for monitoring the clinical outcome in differentiated thyroid cancer (DTC) patients treated without radioactive iodine (RAI).The aim of the study: To evaluate the DRS system in patients with low clinical stage (pT1aN0/Nx).<p class="abste...

Introduction: The activating BRAFV600E is the most common genetic alteration in PTC. There is a common belief that it can correlate with a more aggressive clinical course. The mutation of the CHEK2 gene impairs the repair processes of the damaged DNA. It can be expected that the coexistence of both mutations can be related to a worse clinical course.Aim: To assess the prevalence of the coexistence of the CHEK2 and BRAFV600E mutation...

Introduction: Still there is a discussion about the importance of diagnostic and prognostic relevance BRAFV600E mutation. The wide range of BRAFV600E mutation frequency (40–80%) doesn’t facilitate this task. Population diversity and genotyping methodology are suspected sources of differences seen in the mutation frequencies detected by different studies. The aim of this study was to assess the prevalence BRAF V600...

Introduction: BRAFV600E mutation constitutes 98–99% of all detected mutation in thyroid carcinoma. The remaining 2% are BRAF mutations detected in the vicinity of codon V600. Due to the low incidence not much is known about their importance for the development of papillary thyroid carcinoma (PTC). In addition, some of these mutations co-occur with the mutation BRAFV600E.Methods/design: The study prese...

Introduction: Diagnosis of pheochromocytoma is rarely established in pregnancy, although can cause threat to health and life of foetus and mother. Exact and early diagnosis is crucial for effective treatment.Purpose: The purpose of our study is to present a case of patient with pheochromocytoma and medullary thyroid carcinoma (MCT) – MEN2A syndrome - diagnosed in 9-th week of pregnancy.Material and method: Twenty nine-year-old...

Introduction: 18F- Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (18F-PSMA PET/CT) is currently used in the evaluation of prostate cancer. Due to increased expression of PSMA in the neovascular endothelial cells of malignant lesions other than prostate cancer, PSMA PET/CT has become of interest to researchers in the management of thyroid cancer. The goal of this study was to evaluate the incidence and clinical signifi...

Introduction: Paragangliomas are rare neuroendocrine neoplasms arising from chromaffin cells in the sympathetic or parasympathetic neural paraganglia that may appear in many places throughout the body. These might be benign or malignant tumors. We report an interesting case of disseminated paraganglioma, the diagnosis of which began with the metastasis to the thyroid gland.Case presentation: A 69-year-old patient with a history of toxic multinodular goit...